Project title:
Scalability of cardiovascular intrinsic frequencies: Validations in preclinical models and non-invasive clinical studies

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Grant information:
AHA

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Relevant publications:
Alavi, R., Dai, W., Amlani, F., Rinderknecht, D.G., Kloner, R.A. and Pahlevan, N.M., 2021. Scalability of cardiovascular intrinsic frequencies: validations in preclinical models and non-invasive clinical studies. Life Sciences, 284, p.119880.

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Project description:

This dataset is associated with the published study titled "Scalability of cardiovascular intrinsic frequencies: Validations in preclinical models and non-invasive clinical studies." It includes 
raw and processed data used to investigate the scalability of intrinsic frequency (IF) parameters across species. The files "Sample pressure waveform" and "Intrinsic frequency (IF) 
reconstruction of a carotid waveform with key parameters" contain original pressure waveform data and the corresponding intrinsic frequency reconstruction of the carotid waveform. 
The files "Rabbit intrinsic frequencies (ω1, ω2)", "Rat intrinsic frequencies (ω1, ω2)", and "Human intrinsic frequencies (ω1, ω2)" include data on the physiological regions corresponding 
to the unscaled intrinsic frequencies across species, showing the distribution of ω2 versus ω1 for each species. The file "Physiological regions of scaled intrinsic frequencies across species" 
presents the scaled intrinsic frequency parameters and corresponding physiological regions. It includes (a) the second scaled intrinsic frequency versus the first, and (b, c) waveform 
reconstructions using scaled IF parameters for rats and rabbits compared with clinical human data. The scaled parameters for both animals fall within the physiological range of human data. 
The same file also presents the first and second scaled intrinsic frequencies, their difference, and their relationship with the scaled envelope ratio across species. In "Distribution of scaled IF 
across species," the distribution of scaled IF parameters is shown for young, healthy humans, rats, and rabbits using box-whisker plots overlaid with bee-swarm plots. This includes the first 
and second scaled intrinsic frequencies, their difference, and the scaled envelope ratio. Finally, the file "Uncalibrated carotid waveforms recorded by tonometry, Vivio, and iPhone across 
participants" contains examples of raw carotid waveforms collected from three different clinical participants using three device platforms: tonometry, Vivio, and iPhone. Although presented 
in different units (arbitrary units for each sensor type), the waveform shapes across devices show strong morphological similarities.

Parameter              Description
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omega1_bpm        First intrinsic frequency (beats per minute)
omega2_bpm        Second intrinsic frequency (beats per minute)
Del-omega            Difference between omega1 and omega2
EnvRatio                Envelope ratio
omega1_bar          Normalized omega1 (approach-dependent)
omega2_bar          Normalized omega2 (approach-dependent)

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Software: 
Matlab, Excel
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